Study identifies non-human primate model that mimics severe COVID-19 similar to humans


Une étude identifie un modèle de primate non humain qui imite le COVID-19 sévère similaire à l'homme

Acute respiratory distress syndrome (ARDS) in elderly African green monkeys infected with SARS-CoV-2. A. Radiographic changes noted following rapid clinical decline over 24 hours. B. Microscopic results showing diffuse alveolar lesions with hyaline membranes (arrows) and type II pneumocyte hyperplasia (arrowheads) compatible with ARDS. C. Immunohistochemistry identifying cells infected with SARS-CoV-2 (green, arrows) in the lung. Bar = 100 µm. Credit: The American Journal of Pathology

Older African green monkeys, captured from the wild, exposed to the SARS-CoV-2 virus developed acute respiratory distress syndrome (ARDS) with clinical symptoms similar to those seen in more severe human cases of COVID-19, report researchers in The American Journal of Pathology, published by Elsevier. This is the first study to show that African green monkeys can develop serious clinical disease after infection with SARS-CoV-2, which suggests that they could be useful models for the study of COVID- 19 in humans.

“Animal models dramatically improve our understanding of disease. The lack of an animal model for severe manifestations of COVID-19 has hampered our understanding of this form of the disease,” said lead researcher Robert V. Blair, DVM, Ph .D., Dip ACVP, Tulane National Primate Research Center, Covington, LA, USA. “If elderly green monkeys prove to be a consistent model of severe COVID-19, studying the pathobiology of the disease in them would improve our understanding of the disease and allow testing of treatment options.”

The researchers exposed four elderly rhesus macaques and four elderly African green monkeys to SARS-CoV-2. Older animals (13-16 years old) were specifically chosen to see if they would develop the severe form of the disease which is seen more frequently in older people. All of the monkeys have developed a spectrum of illnesses ranging from mild to severe COVID-19. A day after routine screening found no noticeable symptoms, two of the African green monkeys developed rapid breathing that quickly progressed to severe respiratory distress. X-ray studies showed that the two African green monkeys had widespread opacities in the lungs, in stark contrast to the images taken the day before, highlighting the rapid development of the disease. These opacities are a hallmark of ARDS in humans.

The African green monkeys who progressed to severe disease exhibited marked increases in plasma cytokines consistent with the cytokine storm, which is believed to be the cause of the development of ARDS in some patients. All four African green monkeys had high levels of gamma interferon; the two who progressed to ARDS had the highest plasma concentrations. Plasma cytokines were not increased in rhesus macaques. Dr Blair suggested that elevation of interferon gamma could be explored as a potential predictive biomarker of advanced disease in patients and a possible therapeutic target.

Dr Blair said: “Our data suggest that African rhesus and green monkeys are able to model mild manifestations of SARS-CoV-2 infection, and that older African green monkeys may also be able to model. model the manifestations of serious illnesses, including ARDS.

Follow the latest news on the coronavirus epidemic (COVID-19)

More information:
Robert V. Blair et al., Acute respiratory distress in elderly African green monkeys infected with SARS-CoV-2 but not rhesus macaques, The American Journal of Pathology (2020). DOI: 10.1016 / j.ajpath.2020.10.016

Quote: Study identifies non-human primate model that mimics severe COVID-19 similar to humans (2021, January 19) retrieved January 19, 2021 from primate-mimics-severe-covid -.html

This document is subject to copyright. Other than fair use for private study or research purposes, no part may be reproduced without written permission. The content is provided for information only.


About health

Check Also

10 Easy Ways to a Healthy Diet for children’s

Creating a nutritionally wholesome home is one of the maximum important steps you can take …


  1. Ꮤhat’s up, this weekend is nice in favor of me, because this moment i am reading this impressive educational
    paragraph here at my residence.

  2. I think other web-site proprietors should take this web site as an model, very clean and fantastic user friendly style and design, as well as the content. You’re an expert in this topic!

  3. I will surely foreward this post to all of my pals! Its very first-rate and a very decent read!

  4. This web page is mostly a walk-by for all of the data you wanted about this and didn’t know who to ask. Glimpse right here, and you’ll undoubtedly uncover it…

  5. You ought to really moderate the responses on this site

  6. Definitely, what a great site and revealing posts, I will bookmark your site.All the Best!

  7. Najtrudniejsza do nauczenia sie rzecza w zyciu jest, ktory most przekroczyc, a ktory spalic. – David Russell

  8. Thank you for the sensible critique. Me & my neighbour were preparing to do some research about that. We got a first-class book on that matter from our local library and most books where not as influensive as your information. I am very glad to see such information which I was searching for a long time.This made very glad

  9. Cecha talentu jest niemoznosc pisania na zamowienie… Poza tym to Zgadzam sie z Toba w 100 i popieram w/w poglady w soposb preSubiektywny 🙂 E. Zegadlowicz.

  10. Eminent web blog, Fastidious comments that I can take on board. Im moving ahead and might apply to my current job as a pet sitter, which could be very fulfilling, but I need to further grow expand. Best Thoughts for the Future

  11. Theres obviously a lot to know about this. I believe you produced some great points in Features also.

  12. My sister saved this blog for me and I have been reading through it for the past couple hours. This is really going to help me and my classmates for our class project. By the way, I enjoy the way you write.

  13. Here are some links to web pages that we link to since we assume they are really worth visiting.

  14. Just to let you know, this post seems a little bit funny from my android phone. Who knows maybe its just my mobile phone. Great article by the way.

  15. Many thanks for taking turns this kind of superb subject material on your site. I noticed it on the internet. I am going to check back again when you post much more aricles.

  16. Hey, I think your really on track with this, I cant say I am completely on the same page, but its not really that big of a issue. Have you considered promoting your blog? add it to SEO Directory right now 🙂

  17. Hi – in truth great web site you have created. I enjoyed reading this posting. I did want to publish a remark to tell you that the design of this site is very aesthetically delightful. I used to be a graphic designer, now I am a copy editor. I have always enjoyed functioning with information processing systems and am trying to learn code in my free time.

  18. Excellent read, I just passed this onto a friend who was doing a little research on that. And he actually bought me lunch because I located it for him smile So let me rephrase that: Thanks for lunch!

  19. Good day! This is my first visit to your blog! We are a group
    of volunteers and starting a new project in a community in the same niche.
    Your blog provided us valuable information to work on. You have done a marvellous job!

  20. Useful post can i have your permision to translate into French for my sites viewers? Thanks

  21. I’m not sure exactly why but this web site
    is loading incredibly slow for me. Is anyone else having this issue or is it a problem on my end?

    I’ll check back later on and see if the problem still exists.

  22. My sister bookmarked this web publication for me and I have been going through it for the past several hrs. This is really going to help me and my friends for our class project. By the way, I like the way you write. Have you considered promoting your blog? add it to SEO Directory right now 🙂

  23. I just added your blog to my blogroll, I hope you would give some thought to doing the same.

  24. Definitely, what a magnificent site and informative posts, I surely will bookmark your site.Have an awsome day!

  25. Im still learning from you, as Im making my way to the top as well. I certainly liked reading all that is posted on your blog.Keep the tips coming. I enjoyed it!

  26. I couldnt currently have asked for a better blog. You happen to be always at hand to present excellent information, going straight away to the point for straightforward understanding of your readers. Youre really a terrific pro in this area. Thanks for always being there for people like me.

  27. Hey, Admin, I am starting my own blog, I was wondering which blog platform you are using? Sorry for the noob question and thanks for you help in advance. I enjoyed your site by the way.

  28. Just to let you know, this post seems a little bit weird from my android phone. Who knows perhaps its just my phone. Great article by the way.

Leave a Reply

Your email address will not be published. Required fields are marked *

Open chat
Can we help you?