Deep brain stimulation and exercise restore movement in ataxia

Credit: Public domain Pixabay / CC0

New research from scientists at Baylor College of Medicine shows that a combination of deep brain stimulation (DBS) and exercise has potential benefits for the treatment of ataxia, a rare genetic neurodegenerative disease characterized by progressive, irreversible problems with movement.

Working with a mouse model of the human condition, researchers at Baylor and the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital found that the combination of DBS targeting the cerebellum, a major motor center in the brain, and the exercise saved the coordination of limbs and walking. and that the benefits continued without further stimulation. In addition, the study reports that stimulation of mice with ataxia at an early stage showed the most dramatic improvements. These and other results, published in the journal Nature communications, provide valuable new information in the design of future DBS strategies to treat the human condition.

“People with ataxia usually have progressive movement problems, including balance and coordination problems that affect a person’s ability to walk, speak and use fine motor skills. There are limited treatment options for this condition, and patients typically survive 15 to 20 years after symptoms. appear for the first time, ”said first author Lauren Miterko, a graduate student of Dr. Roy Sillitoe’s lab at Baylor.

DBS is currently used to relieve motor dysfunction in Parkinson’s disease and other movement conditions, but its value in the treatment of ataxia has not been widely explored. In this study, the researchers worked with Car8, a mouse model of inherited ataxia to determine whether adjusting DBS parameters and the location of the stimulation target would help increase the effectiveness of treatment for the disease.

Frequency matters

“We first targeted the cerebellum because it is a primary motor center in the brain and this target location for DBS has seen encouraging success in treating motor problems associated with other conditions, such as stroke. “said Miterko. “We systematically targeted the cerebellum with different frequencies of DBS and determined if there was an optimal frequency that would increase the effectiveness of the treatment. When we used a particular frequency, 13 Hz, that’s when the function motor movement improved in our Car8 mice. ”

DBS plus exercise improved results

Neurostimulation with DBS improved muscle function and general mobility in Car8 mice, but researchers looked for additional ways to improve the condition.

“We know that exercise in general can benefit both muscle and neuronal health, and previous work in Parkinson’s disease and stroke patients has mentioned that neuromodulation techniques combined with physical stimulation had benefits, so we decided to include exercise in our investigation, ”Miterko said. “We found that when animals received DBS during exercise on a treadmill, there were improvements in motor coordination and gait that we did not see with DBS alone.”

“In our model of ataxia, the improvements did not disappear after a week of treatment, which has important practical implications for potential clinical applications,” said co-author Dr Meike E. van der Heijden, Associate postdoctoral fellow at the Sillitoe laboratory. “Additionally, all of the young mice with early-stage ataxia responded, suggesting that it is possible that early treatment may also offer the greatest benefit to patients in the future.

The researchers also obtained information on the type of brain cells involved in the process of restoring movement in this mouse model of ataxia. They found that neurotransmission of Purkinje cells is necessary for DBS to be effective. Purkinje cells are a type of neuron located in the cerebellar cortex of the brain. These cells are involved in the regulation of movement, balance and coordination among other functions.

“One of our goals is to better elucidate the role Purkinje cells play in recovery from ataxia,” said van der Heijden.

“We are particularly excited by the results of this study as it is possible to extrapolate our approach to treat not only other motor diseases, but possibly non-motor neuropsychiatric conditions as well,” said the corresponding author, the Dr Roy Sillitoe, Associate Professor of Pathology. and Immunology and Neuroscience at Baylor College of Medicine, and Director of the Center for Neuropathology at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital.

Scientists shed new light on the neural basis of tremors

More information:
Lauren N. Miterko et al, Neuromodulation of the cerebellum saves movement in a mouse model of ataxia, Nature communications (2021). DOI: 10.1038 / s41467-021-21417-8

Provided by Baylor College of Medicine

Quote: Deep Brain Stimulation and Exercise Restore Movement in Ataxia (2021, February 26) retrieved February 27, 2021 from html

This document is subject to copyright. Other than fair use for private study or research purposes, no part may be reproduced without written permission. The content is provided for information only.

If you liked the topic, share it on social media for everyone to benefit

About health

Check Also

10 Easy Ways to a Healthy Diet for children’s

Creating a nutritionally wholesome home is one of the maximum important steps you can take …


  1. Hello to every one,since I am genuinely kedn of reading this website’s post to be updated regularly.
    It carries nice data.

  2. What’s up, after reading this awesome post i am
    as well delighted to share myy experience here with friends.

  3. Greetings! Very helpful advice inn this particular article!
    It’s the little changes thast make the most importnt changes.
    Many thanks forr sharing!

  4. What’s up, I wish foor to subscribe for this blog to
    take most recent updates, so where can i do it please help out.

  5. Well composed articles likme yours renews my faith in today’s writers.You’ve written information I can finally agree on and also use.Manyy thanks for

  6. Way cool! Some very valid points! I appreciate you penning this post
    and the rest of thhe website is also really good.

  7. Hi tere to eveery body, it’s my frst go to see of this webpage;
    this webpage contains amazing and really excellent data in support of readers.

  8. Wow, amazing boog layout! How loong have you beden blogging for?
    you made blogging look easy. The overall look of your weeb site is excellent,as
    well aas the content.

  9. Hello, after reading this amazing article i am as weell happy to
    share my familiarity here wwith mates!

  10. I need to to thank you for this fazntastic read!!
    I definitely enjoyed every bit of it.I have got you book-marked
    too look at new things you post…

  11. Hi there to every body, it’s my first pay a quick visit of this website; this blog
    contains awesome and genuiney excellent data for visitors.

  12. You need to take part in a contest for one of the most useful websites online.
    I will recommend this site!

  13. Hello! I wiish to say that this post is awesome, great written and
    come with approximately all important infos.
    I’d like to look extra posts like this! 🙂

  14. Well composed articles like yours renews my faith iin today’s writers.You’ve written information I can finally agree on and alsso use.Many thanks for

  15. I do not even know how I ended up here, but I thought
    thiss poset was great. I don’t know who you are but certainly you are going
    to a famous blogger if you are not already 🙂 Cheers!

  16. Thank you for this very good posts. I was wanting to know whether you were planning of
    publishing similar posts to this. Keep uup writing superb
    content articles!

  17. Wow, this article is nice, my sister is analyzing such things, soo I aam going to inform her.

  18. Hello all, here every person is sharing such know-how, so it’s pleasant to read this
    website, and I used to go to see this website daily.

  19. Pretty! This has been an extreemely wonderful post.Thank you forr supplying this info.

  20. Great post! We will be linking to this great post on our website.
    Keep up the great writing.

  21. Pretty! This has been an extremely wonderful post.

    Thanks for providing this info.

  22. Nice post. I was checking continuously this blog and I’m
    impressed! Veery useful information specially the last part 🙂
    I care for such info a lot. I was looking for ths parfticular infoormation for a
    long time. Thank yoou and best of luck.

  23. Nice blog here! Also your web site a lot up very fast!
    I desire my site loaded up as quickly ass yours…

  24. It抯 really a nice and useful piece of info. I am glad that you just shared this helpful information with us. Please stay us up to date like this. Thank you for sharing.

  25. I have been absent for some time, but now I remember why I used to love this blog. Thanks , I will try and check back more frequently. How frequently you update your website?

  26. Howdy just wanted to give you a quick heads up. The words in your post seem to be running off the screen in Ie. I’m not sure if this is a formatting issue or something to do with web browser compatibility but I thought I’d post to let you know. The style and design look great though! Hope you get the issue resolved soon. Many thanks

  27. I have been examinating out a few of your posts and i can claim clever stuff. I will definitely bookmark your website.

  28. I have been exploring for a little bit for any high-quality articles or weblog posts in this kind of area . Exploring in Yahoo I eventually stumbled upon this web site. Studying this information So i am glad to show that I have an incredibly good uncanny feeling I found out exactly what I needed. I most without a doubt will make certain to don抰 forget this website and give it a look on a relentless basis.

  29. I just could not depart your website prior to suggesting that I really enjoyed the standard information a person provide for your visitors? Is gonna be back often to check up on new posts

  30. I appreciate, cause I found exactly what I was taking a look for. You have ended my four day lengthy hunt! God Bless you man. Have a nice day. Bye

  31. Interesting post here. One thing I would like to say is most professional fields consider the Bachelor Degree as the entry level standard for an online college degree. Whilst Associate Diplomas are a great way to begin with, completing the Bachelors presents you with many entrance doors to various employment goodies, there are numerous online Bachelor Diploma Programs available coming from institutions like The University of Phoenix, Intercontinental University Online and Kaplan. Another thing is that many brick and mortar institutions offer you Online versions of their college diplomas but typically for a considerably higher charge than the companies that specialize in online degree programs.

  32. I think this is one of the most significant information for me. And i’m glad reading your article. But should remark on some general things, The site style is wonderful, the articles is really nice : D. Good job, cheers

  33. Thanks for this glorious article. One other thing is that almost all digital cameras can come equipped with some sort of zoom lens that enables more or less of your scene to be included by way of ‘zooming’ in and out. Most of these changes in focusing length tend to be reflected inside the viewfinder and on big display screen right on the back of the exact camera.

  34. I am grateful for your post. I’d like to write my opinion that the tariff of car insurance varies from one plan to another, due to the fact there are so many different issues which contribute to the overall cost. For example, the brand name of the automobile will have a large bearing on the cost. A reliable outdated family automobile will have a lower priced premium than the usual flashy fancy car.

  35. You are really a good webmaster, you have done a well job on this topic!

  36. That is very attention-grabbing, You are an excessively professional blogger. I have joined your feed and stay up for seeking extra of your excellent post. Additionally, I’ve shared your website in my social networks!

Leave a Reply

Your email address will not be published. Required fields are marked *

Open chat
Can we help you?